Motor phenotypes and molecular networks associated with germline deficiency of Ciz1
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- 作者：Jianfeng Xiao ; Satya R. Vemula ; Yi Xue ; Mohammad M. Khan ; Korah P. Kuruvilla ; Esther M. Marquez-Lona ; Madison R. Cobb ; Mark S. LeDoux ; mledoux@uthsc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：CIZ1 ; Knock-out mouse ; Dystonia ; Cell cycle ; Cerebellum ; Gene expression
- 刊名：Experimental Neurology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：283
- 期：part_PA
- 页码：110-120
- 全文大小：1296 K
文摘
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In brain, the highest levels of Ciz1 expression were found in cerebellum.
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Ciz1 knock-out mice on the C57BL/6J background did not manifest dystonia.
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Ciz1 knock-out mice showed impaired performance on the rotarod and raised-beam task.
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NF-κB was a major hub for up-regulated genes in Ciz1 knock-out mouse cerebellum.
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TCF7L2 was a major hub for down-regulated genes in Ciz1 knock-out mouse cerebellum.