Osteoarthritis and mortality: A prospective cohort study and systematic review with meta-analysis

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• 作者：Nicola Veronese ; MDp>ap>p> ; p>p>1p> ; Emanuele Cereda ; MDp>bp>p> ; p>p>1p> ; Stefania Maggi ; MDp>cp> ; Claudio Luchini ; MDp>dp> ; Marco Solmi ; MDp>ep>p> ; p>p>fp> ; Toby Smith ; PhDp>gp> ; Michael Denkinger ; MDp>hp>p> ; p>p>ip> ; Michael Hurley ; PhDp>jp> ; Trevor Thompson ; PhDp>kp> ; Enzo Manzato ; MDp>ap>p> ; p>p>cp> ; Giuseppe Sergi ; MDp>ap> ; Brendon Stubbs ; PhDp>lp>p> ; p>p>mp>p> ; p>p>brendon.stubbs@kcl.ac.uk" class="auth_mail" title="E-mail the corresponding authorp>p> ; p>p>brendonstubbs@hotmail.com" class="auth_mail" title="E-mail the corresponding authorp>
• 关键词：Osteoarthritis ; Mortality ; Cardiovascular disease
• 刊名：Seminars in Arthritis and Rheumatism
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：46
• 期：2
• 页码：160-167
• 全文大小：770 K

文摘

Osteoarthritis (OA) is a leading cause of disability, but the relationship with premature mortality remains uncertain. We aimed to investigate the relationship between OA and mortality from any cause and from cardiovascular disease (CVD).p>

Methods

<p id="sp0060">Electronic literature databases searches were conducted to identify prospective studies comparing mortality in a sample of people with and without OA. Risk of all-cause and CVD mortality were summarized using adjusted hazard ratios (HRs) for joint specific (hand, hip, and knee) and joint non-specific OA. New data from the Progetto Veneto Anziani (PRO.V.A.) study were also included.p>

Results

<p id="sp0065">From the PRO.V.A. study (m>Nm> = 2927), there was no significant increase in mortality risk for participants with any joint OA (m>Nm> = 1858) compared to non-OA (all-cause, HR = 0.95, 95% CI: 0.77–1.15 and CVD, HR = 1.12, 95% CI: 0.82–1.54). On meta-analysis, seven studies (OA = 10,018/non-OA = 18,541), with a median 12-year follow-up, reported no increased risk of any-cause mortality in those with OA (HR = 1.10, 95% CI: 0.97–1.25). After removing data on hand OA, a significant association between OA and mortality was observed (HR = 1.18, 95% CI: 1.08–1.28). There was a significant higher risk of overall mortality for (1) studies conducted in Europe, (2) patients with multi-joint OA; and (3) a radiological diagnosis of OA. OA was associated with significantly higher CVD mortality (HR = 1.21, 95% CI: 1.10–1.34).p>

Conclusions

<p id="sp0070">People with OA are at increased risk of death due to CVD. The relationship with overall mortality is less clear and may be moderated by the presence of hand OA.