- 作者：Antonio Ceriello ; Mirian Lansink ; Carlette H.F.C. Rouws ; Katrien M.J. van Laere ; Gary S. Frost
- 关键词：Diabetes mellitus ; Enteral nutrition ; 24 h glucose profile ; Postprandial glucose
- 刊名：Diabetes Research and Clinical Practice
- 出版年：2009
- 出版时间：June 2009
- 年：2009
- 卷：84
- 期：3
- 页码：259-266
- 全文大小：307 K
AimsStudy the effect of several boluses of a new diabetes-specific formula (DSF) during the day on 24 h glucose profile.Methods
In this randomized, controlled, double-blind, cross-over study 12 ambulatory type 2 diabetic patients were included. Subjects received a new DSF and an isocaloric standard fibre-containing formula (SF) while continuing their anti-diabetic medication. Subjects received 100 % of their calculated daily energy requirements as bolus feeding every 3 h (5 times/day, starting at 8.00 a.m. ± 1 h).
Results
Glucose profiles were significantly better after administration of DSF compared with SF determined as mean glucose concentration (±SEM) (8.7 ± 0.5 versus 9.6 ± 0.6 mmol/L, p < 0.05 during 24 h; 9.4 ± 0.6 versus 10.7 ± 0.6 mmol/L, p < 0.001 during daytime) or as incremental area under the curve during daytime (−44 % ; p < 0.05). Subjects receiving DSF experienced less hyperglycaemic time over 24 h (−26 % ; p < 0.05) and during daytime (−30 % ; p < 0.05). Furthermore, lower individual and mean (delta) peak glucose levels were found (p < 0.05). No clinically relevant differences in gastrointestinal tolerance were observed.
Conclusions
Using DSF resulted in significantly better 24 h and postprandial glucose profiles than fibre-containing SF after bolus administration and may therefore help to improve glycaemic control in diabetic patients.