Irradiation of fluvastatin in water: Structure elucidation of photoproducts
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- 作者：Flavio Cermola ; Marina DellaGreca ; Maria Rosaria Iesce ; Sara Montanaro ; Lucio Previtera ; Fabio Temussi ; Marcello Brigante
- 关键词：Fluvastatin ; Benzocarbazole derivatives ; Lactam ; Photocyclization ; Photooxygenation
- 刊名：Journal of Photochemistry and Photobiology A: Chemistry
- 出版年：2007
- 出版时间：25 June 2007
- 年：2007
- 卷：189
- 期：2-3
- 页码：264-271
- 全文大小：389 K
文摘
Fluvastatin is easily transformed in water by solar irradiation. One day-light exposure induces a complete degradation of the drug and formation of a mixture of products. Different chromatographic processes led to the isolation of dihydrobenzocarbazole, benzocarbazole, azonane-2,7-dione and spiro[4.4]azononane derivatives. Structures of photoproducts were elucidated by spectroscopic means. Photocyclization and photooxygenation are the main reactions involved in the formation of the observed products.