Pyomyoma is a rare disease but carries high morbidity and mortality. Because of the non-specific nature of the symptoms, subacute course of the disease and its low incidence, early diagnosis is difficult. We report a case of septic shock due to pyomyoma after a miscarriage in the second trimester of pregnancy. Because of the torpid clinical course ¨Cdespite the use of a broad-spectrum antibiotic?hysterectomy was performed. When there are signs of infection in a patient with myomas and a recent history of uterine instrumentation, the presence of a pyomyoma must be excluded.