Post-translational modifications in Plasmodium

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• 作者：Duk-Won Doug Chung ; Nadia Ponts ; Serena Cervantes ; Karine G. Le Roch
• 关键词：Plasmodium ; Post-translational modification ; Kinases ; Proteases ; Ubiquitin system ; Life-cycle regulation
• 刊名：Molecular and Biochemical Parasitology
• 出版年：2009
• 出版时间：December 2009
• 年：2009
• 卷：168
• 期：2
• 页码：123-134
• 全文大小：654 K

文摘

Recent evidences indicate that transcription in Plasmodium may be hard-wired and rigid, deviating from the classical model of transcriptional gene regulation. Thus, it is important that other regulatory pathways be investigated as a comprehensive effort to curb the deadly malarial parasite. Research in post-translational modifications in Plasmodium is an emerging field that may provide new venues for drug discovery and potential new insights into how parasitic protozoans regulate their life cycle. Here, we discuss the recent findings of post-translational modifications in Plasmodium.