Poly (ADP-ribose) polymerase inhibitors selectively induce cytotoxicity in TCF3-HLF-positive leukemic cells

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• 作者：Jinhua Piao^a ; Shiori Takai^a ; Takahiro Kamiya^b ; Takeshi Inukai^c ; Kanji Sugita^c ; Kazuma Ohyashiki^d ; Domenico Delia^e ; Mitsuko Masutani^f ; Shuki Mizutani^a ; ^{skkmiz@gmail.com} ; Masatoshi Takagi^a ; ^{m.takagi.ped@tmd.ac.jp}
• 关键词：Acute lymphoblastic leukemia ; TCF3-HLF ; Homologous recombination repair ; PARP inhibitor
• 刊名：Cancer Letters
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：386
• 期：Complete
• 页码：131-140
• 全文大小：1639 K
• 卷排序：386

文摘

TCF3 (E2A)-HLF-positive leukemia exhibits sensitivity to PARP inhibitor. TCF3-HLF expression suppressed homologous recombination repair activity. TCF3-HLF expression suppressed MCPH1 level.