Neuroligin 2 deletion alters inhibitory synapse function and anxiety-associated neuronal activation in the amygdala
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- 作者：Olga Babaeva ; Paolo Bottab ; Elisabeth Meyerb ; Christian Mü ; llerb ; Hannelore Ehrenreichc ; Nils Brosea ; Andreas Lü ; thib ; Dilja Krueger-Burga ; krueger@em.mpg.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Neuroligins ; Amygdala ; Anxiety ; Gephyrin ; Inhibitory synapse ; cFos
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：100
- 期：Complete
- 页码：56-65
- 全文大小：3421 K
文摘
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Nlgn2 is localized to inhibitory synapses in mouse basal amygdala.
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Perisomatic inhibitory postsynapses are altered in Nlgn2 knockout mouse amygdala.
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Inhibitory synaptic transmission is impaired in Nlgn2 knockout mouse amygdala.
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Nlgn2 knockout mice show a robust anxiety phenotype.
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Induction of cFos under anxiogenic conditions is exaggerated in Nlgn2 knockout mice.