The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons
详细信息 查看全文
- 作者：Elizabeth. C. Carroll1 ; Lei Jin2 ; Andres Mori1 ; Natalia Muñ ; oz-Wolf1 ; Ewa Oleszycka1 ; Hannah B.T. Moran1 ; Samira Mansouri2 ; Craig P. McEntee1 ; Eimear Lambe1 ; Else Marie Agger3 ; Peter Andersen3 ; Colm Cunningham5 ; Paul Hertzog4 ; Katherine A. Fitzgerald6 ; 7 ; Andrew G. Bowie8 ; Ed C. Lavelle1 ; 9 ; lavellee@tcd.ie" class="auth_mail" title="E-mail the corresponding author
- 刊名：Immunity
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：44
- 期：3
- 页码：597-608
- 全文大小：3299 K
文摘
- •
The adjuvant chitosan promotes DC maturation by inducing type I interferons
- •
Chitosan-triggered type I interferons and DC maturation requires cGAS and STING
- •
ROS and cytoplasmic DNA are necessary for chitosan to drive type I interferons
- •
Promotion of Th1 responses by chitosan requires IFNAR, cGAS, and STING