Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4
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- 作者：Warrison A. Andrade1 ; 2 ; Sarika Agarwal1 ; Shunyan Mo3 ; 4 ; Scott A. Shaffer3 ; 4 ; Joseph P. Dillard5 ; Tobias Schmidt6 ; Veit Hornung6 ; Katherine A. Fitzgerald1 ; 2 ; 7 ; Evelyn A. Kurt-Jones1 ; 2 ; Douglas T. Golenbock1 ; 2 ; 8 ; douglas.golenbock@umassmed.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：type I interferon ; cGAS ; STING ; TLR4 ; Neisseria gonorrhoeae
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：14 June 2016
- 年：2016
- 卷：15
- 期：11
- 页码：2438-2448
- 全文大小：1937 K
文摘
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Induction of type I IFN by Neisseria gonorrhoeae depends on the cGAS/STING axis
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Complete induction of type I IFN is dependent on both cGAS/STING and TLR4 pathways
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Neisseria gonorrhoeae infection induces the production of noncanonical 2′3′-cGAMP
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Type I IFN is detrimental for Neisseria gonorrhoeae killing by murine macrophages