Sumoylation Promotes the Stability of the DNA Sensor cGAS and the Adaptor STING to Regulate the Kinetics of Response to DNA Virus
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- 作者：Ming-Ming Hu1 ; 2 ; Qing Yang1 ; 2 ; Xue-Qin Xie2 ; Chen-Yang Liao2 ; Heng Lin1 ; Tian-Tian Liu1 ; 2 ; Lei Yin1 ; Hong-Bing Shu1 ; 2 ; 3 ; 4 ; shuh@whu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 刊名：Immunity
- 出版年：2016
- 出版时间：20 September 2016
- 年：2016
- 卷：45
- 期：3
- 页码：555-569
- 全文大小：4074 K
文摘
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Trim38 deficiency enhances susceptibility to DNA virus infection
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Sumoylation of cGas and Sting promotes their stability during early infection
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In the late phase of infection, cGas and Sting are desumoylated by Senp2
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Desumoylation of cGas and Sting leads to their degradation by different mechanisms