Sarcolemmal α2-adrenoceptors control protective cardiomyocyte-delimited sympathoadrenal response

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• 作者：Yuri M. Kokoz^a ; ^{yuryikokoz@gmail.com} ; Edward V. Evdokimovskii^a ; ^{onletaet@gmail.com} ; Alexander V. Maltsev^a ; ^{goicr@rambler.ru} ; Miroslav N. Nenov^a ; ^b ; ^{mnnenov@utmb.edu} ; Olga V. Nakipova^c ; ^{olga.nakipova@gmail.com} ; Alexey S. Averin^c ; ^{averinas82@gmail.com} ; Oleg Yu. Pimenov^a ; ^{poleg237@rambler.ru} ; Ilia Y. Teplov^c ; ^{T.I.Y@mail.ru} ; Alexey V. Berezhnov^c ; ^{g_56@rambler.ru} ; Santiago Reyes^d ; ^{reyesramirez.santiago@mayo.edu} ; Alexey E. Alekseev^d ; ^{alekseev.alexey@mayo.edu}
• 关键词：7NI ; 7-nitroindazole ; NOS inhibitor ; 8Br-cGMP ; 8-bromoguanosine 3&prime ; 5&prime ; -cyclic monophosphate ; membrane permeable cGMP analog ; Akt/PKB ; Akt or protein kinase B ; serine/threonine-specific protein kinase ; DAF-FM ; 4-amino-5-methylamino-2&prime ; 7&prime ; -Difluorofluorescein ; eNOS ; endothelial NO synthase ; ICaL ; voltage-gated L-type Ca2+ current ; NE ; norepinephrine ; NO ; nitric oxide ; PDE ; phosphodiesterase ; PKA ; cAMP-dependent protein kinase ; PKG ; cGMP-dependent protein kinase ; PP1 and PP2A
• 刊名：Journal of Molecular and Cellular Cardiology
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：100
• 期：Complete
• 页码：9-20
• 全文大小：1473 K
• 卷排序：100

文摘

α2-AR in cardiomyocytes suppress voltage-gated L-type Ca2 + channels (ICaL). NO-dependent α2-AR signaling suppresses ICaL via cGPM - PKG-dependent routes. α2-AR signaling alters kinase-phosphatase balance opposing β-adrenergic stimulation. α2-AR control [Ca2 +]in and contractility outcomes during catecholamine surge. aberrant α2-AR signaling in SHR cardiomyocytes may be linked to cardiac hypertrophy.