F-cell levels are altered with erythrocyte density in sickle cell disease

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• 作者：Sumanta Basu^a ; ¹ ; Bisnu Prasad Dash^b ; Dilip Kumar Patel^c ; Sudipa Chakravarty^d ; Amit Chakravarty^d ; Debashis Banerjee^e ; Abhijit Chakrabarti^a ; ^{abhijit.chakrabarti@saha.ac.in"" rel=""nofollow}
• 关键词：Membrane asymmetry ; Glycophorin ; F-cells ; Aging ; Flow cytometry
• 刊名：Blood Cells, Molecules, and Diseases
• 出版年：2011
• 出版时间：15 August 2011
• 年：2011
• 卷：47
• 期：2
• 页码：117-119
• 全文大小：229 K

文摘

Lighter cells from density fractionated erythrocytes of sickle cell disease (SCD) patients carry higher amount of externalized phosphatidylserine (PS) and cell surface glycophorins compared to the denser counterparts. Further analysis also revealed that the denser cells contained higher levels of fetal hemoglobin (HbF) compared to the lighter cells, supported by the presence of larger number of F-cells in these populations. In this report, we have found direct evidence on the higher survival of the HbF rich erythrocytes in SCD.