Arsenic-induced dose-dependent modulation of the NF-κB/IL-6 axis in thymocytes triggers differential immune responses
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- 作者：Sreetama Choudhurya ; Payal Guptaa ; Sayan Ghosha ; Sudeshna Mukherjeea ; Priyanka Chakrabortya ; Urmi Chatterjib ; Sreya Chattopadhyaya ; scphys@caluniv.ac.in" class="auth_mail" title="E-mail the corresponding author ; sreyachatterjee@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; sreyasaha@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Arsenic ; Thymus ; Oxidative stress ; Apoptosis ; NF-κB/IL-6/STAT3 ; nTreg
- 刊名：Toxicology
- 出版年：2016
- 出版时间：16 May 2016
- 年：2016
- 卷：357-358
- 期：Complete
- 页码：85-96
- 全文大小：3415 K
文摘
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We for the first time explicitly show that arsenic exposure causes morphological damage to the thymus and results in heightened death of thymocytes.
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Our data suggests that arsenic-induced apoptosis occurs due to increase in cellular oxidative and nitrosative stress.
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We have for the first time established a non-classical role of NF-κB, correlating it with increase in FoxP3 expression.
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The % of CD4+ CD25+ T cells were high and expression of FoxP3 has also increased at higher doses of arsenic indicating an nTreg bias.