Hypothermia for neonatal hypoxic-ischemic encephalopathy: NICHD Neonatal Research Network contribution to the field

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• 作者：Seetha Shankaran ; MD^a ; ^{sshankar@med.wayne.edu" class="auth_mail" title="E-mail the corresponding author} ; Girija Natarajan ; MD^a ; Lina Chalak ; MD^b ; Athina Pappas ; MD^a ; Scott A. McDonald ; BS^c ; Abbot R. Laptook ; MD^d
• 关键词：Neonatal ; Hypoxic-ischemic encephalopathy ; Hypothermia Neuroprotection ; Biomarkers
• 刊名：Seminars in Perinatology
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：40
• 期：6
• 页码：385-390
• 全文大小：381 K

文摘

In this article, we summarize the NICHD Neonatal Research Network (NRN) trial of whole-body hypothermia for neonates with hypoxic–ischemic encephalopathy in relation to other randomized controlled trials (RCTs) of hypothermia neuroprotection. We describe the NRN secondary studies that have been published in the past 10 years evaluating clinical, genetic, biochemical, and imaging biomarkers of outcome.