The Greenland shark: A new challenge for the oxidative stress theory of ageing?

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• 作者：David Costantini^a ; ^b ; ^{davidcostantini@libero.it} ; Shona Smith^b ; Shaun S. Killen^b ; Julius Nielsen^c ; John F. Steffensen^c
• 关键词：Ageing ; Lifespan ; Oxidative stress ; Sharks ; Vertebrates
• 刊名：Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：203
• 期：Complete
• 页码：227-232
• 全文大小：417 K
• 卷排序：203

文摘

The free radical theory of ageing predicts that long-lived species should be more resistant to oxidative damage than short-lived species. Although many studies support this theory, recent studies found notable exceptions that challenge the generality of this theory. In this study, we have analysed the oxidative status of the Greenland shark (Somniosus microcephalus), which has recently been found as the longest living vertebrate animal known to science with a lifespan of at least 272 years. As compared to other species, the Greenland shark had body mass-corrected values of muscle glutathione peroxidase and red blood cells protein carbonyls (metric of protein oxidative damage) above 75 percentile and below 25 percentile, respectively. None of the biochemical metrics of oxidative status measured in either skeletal muscle or red blood cells were correlated with maximum lifespan of species. We propose that the values of metrics of oxidative status we measured might be linked to ecological features (e.g., adaptation to cold waters and deep dives) of this shark species rather to its lifespan.