The Activated Macrophage Colony-Stimulating Factor (CSF-1) Receptor as a Predictor of Poor Outcome in Advanced Epithelial Ovarian Carcinoma

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• 作者：Toy ; Eugene P. ; Chambers ; Joseph T. ; Kacinski ; Barry M. ; Flick ; Maryann B. ; Chambers ; Setsuko K.
• 刊名：Gynecologic Oncology
• 出版年：2001
• 出版时间：February, 2001
• 年：2001
• 卷：80
• 期：2
• 页码：194-200
• 全文大小：238 K

文摘

Objective. We have previously shown that the macrophage colony-stimulating factor receptor (CSF-1R) and its ligand, CSF-1, together predict poor prognosis in epithelial ovarian carcinoma. The activated or phosphorylated form of CSF-1R (CSF-1Rphos) has been associated with enhanced invasive and metastatic potential. Our goal is to correlate CSF-1Rphos with known prognostic factors and to determine its role in predicting outcome in advanced ovarian cancer.