Urine proteome analysis in Dent's disease shows high selective changes potentially involved in chronic renal damage
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- 作者：Laura Santuccib ; Giovanni Candianob ; Franca Anglanid ; Maurizio Bruschib ; Enrica Tosettod ; Daniela Cremascod ; Luisa Murere ; Chiara D'Ambrosioc ; Andrea Scalonic ; Andrea Petrettof ; Gianluca Caridia ; Roberta Rossia ; Alice Bonannia ; Gian Marco Ghiggeria ; b ; GMarcoGhiggeri@ospedale-gaslini.ge.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：CLCN5 gene ; Dent's disease ; Fibrosis ; Chronic renal failure ; Metalloproteases ; TIMPs
- 刊名：Journal of Proteomics
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：130
- 期：Complete
- 页码：26-32
- 全文大小：774 K
文摘
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Differences in urine protein composition due to genetic variability are a main problem for defining biomarkers
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Large monogenic pedigrees with reduced genetic background are potentially good models to characterise urinary biomarkers in selected disease
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Characterizing a large family with Dent's disease led to definition of specific biomarkers.
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Gene ontology analysis revealed high urinary levels of at least 15 protein clusters.
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Proteins involved in extracellular matrix remodelling was a major group of interest.