Granulocyte Colony Stimulating Factor-induced Exacerbation of Fungus-related Immune Restoration Inflammatory Syndrome: A Case of Chronic Disseminated Candidiasis Exacerbation

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• 作者：Marie-Olivia Chandesris^a ; ^b ; ^{olivia.chandesris@nck.aphp.fr} ; Charikleia Kelaidi^c ; Fré ; dé ; ric Mé ; chaï ; ^a ; Marie-Elisabeth Bougnoux^d ; Nicole Brousse^e ; Jean-Paul Viard^a ; Sylvain Poiré ; e^f ; Marc Lecuit^a ; Olivier Hermine^b ; Olivier Lortholary^a
• 关键词：chronic disseminated candidiasis ; hematopoietic growth factors ; hepatosplenic candidiasis ; immune restoration inflammatory syndrome
• 刊名：Journal of Microbiology, Immunology and Infection
• 出版年：2010
• 出版时间：August 2010
• 年：2010
• 卷：43
• 期：4
• 页码：339-343
• 全文大小：453 K

文摘

Chronic disseminated candidiasis is a complication of the intensive therapies of hematological malignancies revealed during hematopoietic recovery, a context reminiscent of the immune restoration inflammatory syndrome in human immunodeficiency virus patients receiving antiretroviral therapy. We report a case of severe exacerbation of chronic disseminated candidiasis after pegylated granulocyte-colony stimulating factor administration. We emphasize the major inflammatory substrate of the disease and suggest that immune-modulating strategies such as hematopoietic growth factors, should be used cautiously in such patients.