Tonic pupil after botulinum toxin-A injection for treatment of esotropia in children
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- 作者：Pediatric Eye Disease Investigator Group&lowast ; ; Stephen P. Christiansen ; MD ; pedig@jaeb.org" class="auth_mail" title="E-mail the corresponding author ; Danielle L. Chandler ; MSPH ; Katherine A. Lee ; MD ; PhD ; Rosanne Superstein ; MD ; Alejandra de Alba Campomanes ; MD ; Erick D. Bothun ; MD ; Julie Morin ; MD ; David K. Wallace ; MD ; MPH ; Raymond T. Kraker ; MSPH
- 刊名：Journal of American Association for Pediatric Ophthalmology and Strabismus
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：20
- 期：1
- 页码：78-81
- 全文大小：542 K
文摘
A total of 27 children with esotropia (mean age, 3.9 years; range, 9 months to 13.8 years) were enrolled in a 9-month observational study following botulinum toxin A (BTX-A) injection of one (n = 7) or both (n = 20) medial rectus muscles. BTX-A dosage ranged from 3.0 to 6.0 units per muscle. Three participants developed tonic pupil, noted at the first follow-up visit, occurring 12-19 days after injection. All 3 cases occurred in the left eye of participants who underwent bilateral BTX-A injection by the same surgeon. Anisocoria diminished from a maximum of 4 mm at the 2-week visit to 1–2 mm in all patients over the 9-month postinjection data collection period. No adverse visual outcomes were noted. Tonic pupil is an infrequently reported complication of BTX-A injection for strabismus. The experience of our investigator group suggests the need for careful injection technique and thorough preinjection counseling.