文摘
Pyrazolo[1,5-a]pyrimidine is an important and versatile scaffold in drug design and discovery. Various synthetic approaches for the preparation of pyrazolo[1,5-a]pyrimidine derivatives are summarized. This review describes the chemical structures of the most active pyrazolo[1,5-a]pyrimidine derivatives. Review focuses on structure activity relationship (SAR) studies of pyrazolo[1,5-a]pyrimidine scaffold. The review shall contribute for planning research on pyrazolo[1,5-a]pyrimidines.