Sensitivity of neural stem cell survival, differentiation and neurite outgrowth within 3D hydrogels to environmental heavy metals
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- 作者：Sameera Tasneem ; Kurt Farrell ; Moo-Yeal Lee ; Chandrasekhar R. Kothapalli ; c.kothapalli@csuohio.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Neurotoxicity ; Heavy metals ; Neural stem cells ; 3D cultures ; Mechanistic pathways
- 刊名：Toxicology Letters
- 出版年：2016
- 出版时间：3 February 2016
- 年：2016
- 卷：242
- 期：Complete
- 页码：9-22
- 全文大小：3081 K
文摘
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Toxic effects of Cd, Hg and Pb on embryonic rat NSCs investigated.
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NSCs exposed to metals within 3D collagen gels, continuously for 14 days.
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Exposure duration and metal dose influenced NSC survival, differentiation and neurite outgrowth.
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Observed degree of toxicity is in the order: lead > mercury > cadmium.
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Mechanisms by which metal ions affect cell phenotype investigated.