Serotonin and interleukin-6: Association with pruritus severity, sleep quality and depression severity in Prurigo Nodularis
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- 作者：Deepthi Kondaa ; Laxmisha Chandrashekara ; laxmishac@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Medha Rajappab ; Shivanand Kattimanic ; Devinder Mohan Thappaa ; P.H. Ananthanarayananb
- 关键词：PN ; Pruritus Nodularis ; IL-6 ; Interleukin-6 ; HDRS-17 ; Hamilton depression rating scale with 17 items ; PSQI ; Pittsbergh sleep quality index
- 刊名：Asian Journal of Psychiatry
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：17
- 期：Complete
- 页码：24-28
- 全文大小：294 K
文摘
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There was increased IL-6 and decreased serotonin in PN.
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Serotonin and IL-6 showed significant correlation with itching severity of PN.
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Immune mediated abnormality of serotonin system may underlie etiology of PN.
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These findings may have implications on the treatment of PN.