Nanomedicine-based paclitaxel induced apoptotic signaling pathways in A562 leukemia cancer cells

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• 作者：Yan Wang^a ; ¹ ; Ling Zhou^a ; ¹ ; Meng Xiao^a ; Zhong-Liang Sun^a ; Chang-Yuan Zhang^b ; ^{changyuanzhang44@163.com}
• 关键词：Leukemia ; Paclitaxel ; Apoptosis ; Polymeric micelles ; Drug delivery
• 刊名：Colloids and Surfaces B: Biointerfaces
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：149
• 期：Complete
• 页码：16-22
• 全文大小：1565 K
• 卷排序：149

文摘

Amphiphilic pH-sensitive micelle increased the therapeutic efficacy of paclitaxel in leukemia. The polymeric micelles increased the antitumor efficacy of PTX against K562 cancer cells. The PTX-M remarkably increased the upregulation of pro-apoptotic protein expression. PTX-M remarkably prolonged the plasma circulation time of PTX .