LXRα represses LPS-induced inflammatory responses by competing with IRF3 for GRIP1 in Kupffer cells
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- 作者：Chun-mu Miaoa ; Kun Hea ; Pei-zhi Lia ; Zuo-jin Liua ; Xi-wen Zhua ; Zhi-bing Oua ; Xiong-zhong Ruanb ; Jian-ping Gonga ; Chang-an Liua ; liuchangan120@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Liver X receptor ; Kupffer cell ; Interferon regulatory factor 3 ; Glucocorticoid receptor-interacting protein 1 ; Nuclear factor-kappa B
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：35
- 期：Complete
- 页码：272-279
- 全文大小：986 K
文摘
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LPS-induced TNF-<alpha >, IFN-<beta > and IL-1 < beta > generation was reduced by pretreatment with LXR < alpha > agonist.
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The LPS-TLR4 signalling pathway involves IRF3 and GRIP1 co-activation of NF-kB.
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LXR < alpha > agonist, T0901317, has little effect on the expression of either IRF3 or GRIP1.
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Agonist-activated LXR < alpha > competes with IRF3 for GRIP1 and this is the mechanism by which TLR4 signalling is inhibited.