Preparation of hemocompatible cellulosic paper based on P(DMAPS)-functionalized surface

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• 作者：Wenzhi Lv^a ; ¹ ; Bingfeng Cai^b ; ¹ ; Youchao Song^b ; Haolin Zhao^b ; Xiao Jiang^a ; Xiaofan Zhou^a ; ^{zxiaofan@njfu.com.cn" class="auth_mail} ; Ruide Yu^c ; Chun Mao^b ; ^{maochun127@aliyun.com" class="auth_mail}
• 关键词：Cellulosic paper ; ATRP ; P(DMAPS) ; Surface modification ; Hemocompatibility
• 刊名：Colloids and Surfaces B: Biointerfaces
• 出版年：1 April, 2014
• 年：2014
• 卷：116
• 期：Complete
• 页码：537-543
• 全文大小：1744 K

文摘

The surface-modification of paper substrates with functional layers is gaining increasing interest, both from academic and industrial research. In this case, the cellulosic paper (CP) surface was functionalized with zwitterionic poly-(3-dimethyl(methacryloyloxyethyl) ammoniumpropane sulfonate) (CP-g-P(DMAPS) via surface-initiated atom transfer radical polymerization (ATRP) technique for enhancing blood compatibility. An obvious increase in graft yield of the functional P(DMAPS) with polymerization time was observed. The new CP-g-P(DMAPS) produced was investigated for its hemocompatibility. The hemocompatibility studied including platelet and whole blood ceels adhesion tests, hemolysis assay, morphological changes of red blood cells (RBCs), coagulation time tests, and complement activation, platelet activation at the molecular level. Most assays had remarkable differences in the presence of the new zwitterionic CP, indicated the importance of the zwitterion for hemocompatibility of CP.