GNB2 is a mediator of lidocaine-induced apoptosis in rat pheochromocytoma PC12 cells
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- 作者：Yonghong Tan1 ; yonghtan@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; yonghongtandoctor@yeah.net" class="auth_mail" title="E-mail the corresponding author ; Qiong Wang1 ; wangtans@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Baisong Zhao zhaobaisong819@163.com" class="auth_mail" title="E-mail the corresponding author ; Yingjun She yjsheh@yeah.net" class="auth_mail" title="E-mail the corresponding author ; Xiaobao Bi bobjuan@sina.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Lidocaine ; GNB ; Cell cycle ; Apoptosis ; 2-DE
- 刊名：Neurotoxicology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：54
- 期：Complete
- 页码：53-64
- 全文大小：4425 K
文摘
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Lidocaine inhibited cell proliferation and cell growth, and enhanced cell apoptosis.
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Seven proteins were identified by 2-DE analysis and LC–MS/MS.
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Using qRT-PCR, we confirmed that lidocaine up-regulated GNB2 with a 6.4-folds change.
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Inhibition the expression of GNB2 by siRNAs attenuated the role of lidocaine.
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Neuronal apoptosis was induced by lidocaine and this effect was mediated by GNB2.