Three-component reaction of triphenylphosphine, dialkyl but-2-ynedioate and arylidene pivaloylacetonitrile for diastereoselective synthesis of densely substituted 2,3-dihydrofurans
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- 作者：Wen-Jie Qi ; Ying Han ; hanying@yzu.edu.cn ; Chang-Zhou Liu ; Chao-Guo Yan ; cgyan@yzu.edu.cn
- 关键词：Multicomponent reaction ; Triphenylphosphine ; But-2-ynedioate ; Pivaloylacetonitrile ; 2 ; 3-Dihydrofuran
- 刊名：Chinese Chemical Letters
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：28
- 期：2
- 页码：442-445
- 全文大小：328 K
- 卷排序：28
文摘
The three-component reaction of triphenylphosphine, dialkyl but-2-ynedioate and arylidene pivaloylacetonitrile in dry methylene dichloride at room temperature resulted in unexpected densely substituted 1-(triphenyl-λ5-phosphanylidene)ethyl)-2,3-dihydrofurans in satisfactory yields with high diastereoselectivity. The relative configuration of the 2,3-dihydrofurans was elucidated by determination of single crystal structures.