Complement proteins C7 and CFH control the stemness of liver cancer cells via LSF-1
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- 作者：Hyang Sook Seola ; Sang Eun Leea ; Joon Seon Songb ; Je-Keun Rheec ; Shree Ram Singhd ; Suhwan Changc ; suhwan.chang@amc.seoul.kr" class="auth_mail" title="E-mail the corresponding author ; Se Jin Janga ; b ; jangsejin@amc.seoul.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Liver tumor-initiating cell ; Complement protein C7 ; CFH ; Stemness factor ; LSF-1 ; HCC
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：1 March 2016
- 年：2016
- 卷：372
- 期：1
- 页码：24-35
- 全文大小：3935 K
文摘
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C7 and CFH are required to maintain stemness in liver cancer cells.
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Knockdown of C7 and CFH expression abrogated tumorsphere formation and induced differentiation.
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Overexpression of C7 and CFH stimulated stemness factor expression as well as in vivo cell growth.
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Complement proteins, C7 or CFH, are upregulated in liver TICs.
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LSF-1 is induced by C7 or CFH and regulates stemness factor expression in liver TICs.