A convenient and efficient approach to synthesize negletein from baicalin
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- 作者：Guihua He&dagger ; ; Yu Gao&dagger ; ; Cailong Li ; Guolin Wu ; Yazhen Li ; Longrong Dong ; Changcang Huang ; Haijun Chen ; chenhaij@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Negletein ; Baicalin ; Reduction ; One-pot ; Methylation
- 刊名：Tetrahedron Letters
- 出版年：2016
- 出版时间：4 May 2016
- 年：2016
- 卷：57
- 期：18
- 页码：2001-2005
- 全文大小：703 K
文摘
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A novel environment-friendly method to access bioactive negletein.
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Methylation through treatment with NaBH4 is reported.
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The procedure has several advantages including large-scale feasibility.
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This synthetic protocol facilitated the biological studies of negletein.
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Chemical synthesis of negletein from baicalin in one-pot.