Surface biomimetic modification with laminin-loaded heparin/poly-l-lysine nanoparticles for improving the biocompatibility

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• 作者：Tao Liu<sup>asup><sup> ; sup><sup>11140021@hyit.edu.cnsup> ; Youdong Hu<sup>bsup><sup> ; sup><sup>1sup> ; Jianying Tan<sup>csup> ; Shihui Liu<sup>asup> ; Junying Chen<sup>csup> ; Xin Guo<sup>asup> ; Changjiang Pan<sup>asup> ; Xia Li<sup>bsup><sup> ; sup><sup>xial_li@qq.comsup>
• 关键词：Heparin ; Biomimetic ; Nanoparticles ; Endothelialization ; Hemocompatibility
• 刊名：Materials Science and Engineering: C
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：71
• 期：Complete
• 页码：929-936
• 全文大小：2012 K
• 卷排序：71

文摘

A novel laminin-loaded anticoagulant nanoparticle was prepared and used for titanium surface modification. The nanoparticle binding density was adjustable by alteration the concentration ratio of heparin and poly-l-lysine. In a certain range of NPs density, the surface was found to selectively direct platelet and vascular cells behavior.