Natural plant flavonoid apigenin directly disrupts Hsp90/Cdc37 complex and inhibits pancreatic cancer cell growth and migration
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- 作者：Jing Hea ; Changwen Ninga ; Yu Wanga ; Tianfang Maa ; He Huanga ; Yubin Geb ; c ; Jingbo Liud ; ljb168@sohu.com" class="auth_mail" title="E-mail the corresponding author ; Yiqun Jianga ; jiangyiq@jlu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Apigenin ; Heat shock protein 90 ; Cell division cycle protein 37 ; SRL-PFAC ; Pancreatic cancer
- 刊名：Journal of Functional Foods
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：18
- 期：part_PA
- 页码：10-21
- 全文大小：2923 K
文摘
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Apigenin can be digested, released and absorbed into blood circulation to accumulate.
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Apigenin directly inhibited Hsp90/Cdc37 interaction with structural specificity.
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The effect of apigenin on Hsp90/Cdc37 did not rely on CK2 activity.
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Apigenin induced downstream kinase client protein degradation.
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Apigenin induced ROS accumulation, inhibited cell proliferation and migration.