Antagonizing Neuronal Toll-like Receptor 2 Prevents Synucleinopathy by Activating Autophagy
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- 作者：Changyoun Kim1 ; 2 ; Edward Rockenstein2 ; Brian Spencer2 ; Hyung-Koo Kim1 ; Anthony Adame2 ; Margarita Trejo2 ; Klodjan Stafa2 ; He-Jin Lee3 ; Seung-Jae Lee1 ; sjlee66@snu.ac.kr" class="auth_mail" title="E-mail the corresponding author ; Eliezer Masliah2 ; emasliah@ucsd.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：27 October 2015
- 年：2015
- 卷：13
- 期：4
- 页码：771-782
- 全文大小：5541 K
文摘
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Activation of Toll-like receptor 2 antagonizes autophagy in neurons
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TLR2 regulates neuronal autophagy via the AKT/mTOR pathway
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Inhibition of the TLR2 pathway reduces neuronal 伪-synuclein aggregation
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Inhibition of TLR2 rescues Lewy body disease models from neurodegeneration