Local calcium signalling is mediated by mechanosensitive ion channels in mesenchymal stem cells

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• 作者：Vladislav I. Chubinskiy-Nadezhdin^a ; ^{vchubinskiy@gmail.com} ; Valeria Y. Vasileva^a ; Natalia A. Pugovkina^a ; Irina O. Vassilieva^a ; Elena A. Morachevskaya^a ; Nikolay N. Nikolsky^a ; Yuri A. Negulyaev^a ; ^b
• 关键词：Mechanotransduction ; Calcium signalling ; Stretch-activated channels ; Mesenchymal stem cells
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：563-568
• 全文大小：1725 K
• 卷排序：482

文摘

Stretch-induced channel activity in human mesenchymal stem cells was analyzed. Functional expression of SACs and Ca2+-sensitive BK and SK channels was shown. Local Ca2+ influx via stretch-activated channels triggers BK channel activity. SK channels are not coupled with SACs despite higher sensitivity to [Ca2+]i. Functional clustering of SACs and BK channels in stem cell membrane is proposed.