BK Channels Are Required for Multisensory Plasticity in the Oculomotor System

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• 作者：Alexandra B. Nelson¹ ; ² ; ³ ; ^{alexandra.nelson@ucsf.edu} ; Michael Faulstich² ; Setareh Moghadam² ; Kimberly Onori² ; Andrea Meredith⁴ ; Sascha du Lac¹ ; ² ; ⁵ ; ⁶ ; ^{sascha@jhmi.edu}
• 关键词：intrinsic plasticity ; vestibular ; optokinetic ; calcium-dependent potassium ; calcium-activated ; vestibulo-ocular reflex ; firing rate potentiation
• 刊名：Neuron
• 出版年：2017
• 出版时间：4 January 2017
• 年：2017
• 卷：93
• 期：1
• 页码：211-220
• 全文大小：1127 K
• 卷排序：93

文摘

Optokinetic reflex plasticity is rapidly triggered by vestibular deprivation Potentiation of intrinsic plasticity in vestibular neurons parallels OKR plasticity Reductions in BK currents increase excitability after vestibular loss BK channel-null mice are unable to increase OKR gain after vestibular loss