Structures of the Human HCN1 Hyperpolarization-Activated Channel

详细信息    查看全文

• 作者：Chia-Hsueh Lee¹ ; Roderick MacKinnon¹ ; ² ; ^{mackinn@rockefeller.edu}
• 关键词：hyperpolarization-activated ion channel ; cardiac and neuronal pacemaker ; rhythmic firing ; atomic structure ; cryo-electron microscopy ; voltage-dependent gating ; ion selectivity
• 刊名：Cell
• 出版年：2017
• 出版时间：12 January 2017
• 年：2017
• 卷：168
• 期：1-2
• 页码：111-120.e11
• 全文大小：9841 K
• 卷排序：168

文摘

Structures of the human HCN1 hyperpolarization-activated channel at 3.5 Å resolution Channel filter adopts a unique conformation, allowing both K+ and Na+ to permeate Long S4 helix and unusual coupling to the pore mediate reversed polarity gating Cyclic AMP induces a rotation of cytoplasmic domains to favor channel opening