刊名:Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
出版年:2017
出版时间:February 2017
年:2017
卷:1863
期:2
页码:560-568
全文大小:1326 K
卷排序:1863
文摘
TRPC6-/- mice show less collagen production and normal lung function in pulmonary fibrosis compared to wild-type controls. TRPC6 expression is up-regulated in TGF-β1-induced lung fibroblast-myofibroblast transdifferentiation. Lack of TRPC6 decreases cell contraction in lung fibroblasts.