Un Myélome Exceptionnel : Le Myélome À IgE

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• 作者：Chantal Houlbert ; Nicole Frenkiel ; Sylvain Lanot ; Mich&#xe8 ; le Malet
• 关键词：Sous-produits de d&#xe9 ; sinfection ; nageurs ; entra&#xee ; nement ; r&#xe9 ; ponses immunes ; immunit&#xe9 ; muqueuse
  Keywords ; Disinfection byproducts ; swimmers ; training ; immune responses ; mucosal immunity
• 刊名：Revue Francophone des Laboratoires
• 出版年：2005
• 出版时间：September-October 2005
• 年：2005
• 卷：2005
• 期：375
• 页码：47-49
• 全文大小：9284 K

文摘

Chloramins, chlorination disinfection byproducts in swimming pool water, are involved in mucosal irritation phenomenons in elite swimmers and lifeguards. Immune modifications have been described after sport activities. Immune abnormalities could be increased by combination of chloramin exposition and intensive training. The objectives of this work were to study systemic and mucosal immune responses in 19 swimmers, before and after training in polluted or clean swimming pool water.

In peripheral blood, lymphocyte subsets and their activation status, and proportions of apoptotic cells were evaluated. In saliva, total IgA levels and specific IgA responses against mucosal bacterias were assayed.

No variation in immune parameters was shown during training in clean water. Significant decreased of activated B lymphocytes was observed after exposition to chloramins. An increase in T lymphocytes, both CD4+ and CD8+, was shown with combined effects of exposition and training. No apoptotic cells were found after exposition and/or intensive training. This study indicates that exposition to chloramines results in mucosal inflammation reactions, not through IgA responses, but by increasing mucosal immune cells' homing.