TGF-beta-induced early gene-1 overexpression promotes oxidative stress protection and actin cytoskeleton rearrangement in human skin fibroblasts
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- 作者：Chloe Leduca ; Lauren Sobilob ; Hechmi Toumic ; Philippe Mondond ; Eric Lespessaillesc ; Fé ; dé ; ric Ossante ; Robin Kurfurstb ; Chantal Pichona ; pichon@cnrs-orleans.fr" class="auth_mail" title="E-mail the corresponding author ; chantal.pichon@cnrs.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：TIEG-1 ; KLF10 ; TGF-β ; Reactive oxygen species ; Rho ; Cofilin ; SMA ; Wound healing
- 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：1860
- 期：6
- 页码：1071-1078
- 全文大小：1559 K
文摘
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Overexpression of TIEG-1 confers resistance to oxidative stress and improves the wound healing feature of fibroblasts.
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A myofibroblast-like conversion is observed with the formation of actin stress fibers and an increase of α-SMA expression.
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The mechanism involves RhoB signaling pathway and the phosphorylation of cofilin and p38 MAPK.