Syntheses, cytotoxic activity evaluation and HQSAR study of 1,2,3-triazole-linked isosteviol derivatives as potential anticancer agents
详细信息 查看全文
- 作者：Cong-Jun Liua ; b ; Yan-Ping Liub ; Shu-Ling Yuc ; Xing-Jie Daia ; Tao Zhanga ; Jing-Chao Taoa ; jctao@zzu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Isosteviol ; Synthesis ; Cytotoxicity ; Click chemistry ; HQSAR
- 刊名：Bioorganic & Medicinal Chemistry Letters
- 出版年：2016
- 出版时间：15 November 2016
- 年：2016
- 卷：26
- 期：22
- 页码：5455-5461
- 全文大小：905 K
文摘
- •
A series of novel 1,2,3-triazole-linked isosteviol derivatives were synthesized.
- •
Their cytotoxicities were assessed against HCT-116 and JEKO-1cell lines.
- •
Compound 10b is promising anticancer agent against HCT-116 (IC50 = 2.987 ± 0.098 μM).
- •
HQSAR studies revealed good predictive model.