Salvianolic acid B improves the disruption of high glucose-mediated brain microvascular endothelial cells via the ROS/HIF-1α/VEGF and miR-200b/VEGF signaling pathways
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- 作者：Ming-chao Yang ; Fu-li You ; Zhe Wang ; Xiang-nan Liu ; Yan-feng Wang ; wyfdoctor_2015@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Tight junction proteins ; Salvianolic acid B ; High glucose ; HIF-1α ; miR-200b
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：6 September 2016
- 年：2016
- 卷：630
- 期：Complete
- 页码：233-240
- 全文大小：1796 K
文摘
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Sal B up-regulated the expression of TJ proteins induced by high glucose.
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Sal B decreased the BBB permeability induced by high glucose.
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Sal B inhibited the expression of HIF-1α and VEGF.
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Sal B inhibited the expression of VEGF via upregulating miR-200b.