Monocyte Chemotactic Protein-1 -2518 Gene Polymorphism and Susceptibility to Spinal Tuberculosis

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• 作者：Qile Gao^a ; Qingbiao Du^b ; Hongqi Zhang^a ; ^{zhq9996@aliyun.com" class="auth_mail} ; ^{zhq9996@yahoo.cn" class="auth_mail} ; Chaofeng Guo^a ; Shijin Lu^a ; Ang Deng^a ; Mingxing Tang^a ; Shaohua Liu^a ; Yuxiang Wang^a ; Jia Huang^a ; Qiang Guo^a
• 关键词：Monocyte chemotactic protein-1 ; Gene polymorphism ; Spinal tuberculosis ; Susceptibility
• 刊名：Archives of Medical Research
• 出版年：February, 2014
• 年：2014
• 卷：45
• 期：2
• 页码：183-187
• 全文大小：117 K

文摘

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Background and Aims

Monocyte chemotactic protein-1 (MCP-1) gene polymorphisms play important roles in regulating immunological reactions and may be associated with pulmonary tuberculosis. However, the relationship between the MCP-1 -2518 gene polymorphism and susceptibility to spinal tuberculosis remains unknown. We undertook this study to investigate the relationships between MCP-1 promoter 2518 genotype frequency and allele polymorphisms and susceptibility to spinal tuberculosis in a Chinese Han population.

Methods

Patients with spinal tuberculosis and healthy volunteers were enrolled between December 2004 and December 2010. MCP-1 -2518 polymorphisms in both groups were detected using polymerase chain reaction and DNA sequencing. MCP-1 genotype was analyzed in all patients. Differences in genotype frequencies between groups were compared using 蠂² tests.

Results

A total of 208 patients with spinal tuberculosis and 210 healthy volunteers were included. The distribution frequencies of MCP-1 -2518 GG, GA and AA genotypes were 36.1, 50.9 and 13.0%, respectively, in the case group and 25.2, 53.8 and 21.0%, respectively, in the control group (p <0.05). MCP-1 -2518 GG genotype was significantly associated with the onset of spinal tuberculosis (OR聽= 2.306, 95% CI聽= 1.273-4.178). The G and A allele frequencies were 61.5% and 38.5%, respectively, in the case group, and 52.1% and 47.9% in the control group (p <0.05), the allele 鈥淕鈥?of MCP-1 -2518 showed an association with an increased risk for spinal tuberculosis: OR聽= 1.777, 95% CI聽= 1.053-2999, p聽= 0.03 in the dominant model; OR聽= 1.67, 95% CI聽= 1.097-2.544, p聽= 0.016 in the recessive model.

Conclusions

The MCP-1 -2518 GG genotype and presence of the G allele may be associated with susceptibility to spinal tuberculosis in the Chinese Han population.