Patients with spinal tuberculosis and healthy volunteers were enrolled between December 2004 and December 2010. MCP-1 -2518 polymorphisms in both groups were detected using polymerase chain reaction and DNA sequencing. MCP-1 genotype was analyzed in all patients. Differences in genotype frequencies between groups were compared using 蠂2 tests.
A total of 208 patients with spinal tuberculosis and 210 healthy volunteers were included. The distribution frequencies of MCP-1 -2518 GG, GA and AA genotypes were 36.1, 50.9 and 13.0%, respectively, in the case group and 25.2, 53.8 and 21.0%, respectively, in the control group (p <0.05). MCP-1 -2518 GG genotype was significantly associated with the onset of spinal tuberculosis (OR聽= 2.306, 95% CI聽= 1.273-4.178). The G and A allele frequencies were 61.5% and 38.5%, respectively, in the case group, and 52.1% and 47.9% in the control group (p <0.05), the allele 鈥淕鈥?of MCP-1 -2518 showed an association with an increased risk for spinal tuberculosis: OR聽= 1.777, 95% CI聽= 1.053-2999, p聽= 0.03 in the dominant model; OR聽= 1.67, 95% CI聽= 1.097-2.544, p聽= 0.016 in the recessive model.
The MCP-1 -2518 GG genotype and presence of the G allele may be associated with susceptibility to spinal tuberculosis in the Chinese Han population.