pH-responsive metallo-supramolecular nanogel for synergistic chemo-photodynamic therapy

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• 作者：Xuemei Yao^a ; Li Chen^a ; ^{chenl686@nenu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Xiaofei Chen^a ; Zhigang Xie^b ; Jianxun Ding^b ; Chaoliang He^b ; Jingping Zhang^a ; Xuesi Chen^b
• 关键词：Chemo-photodynamic therapy ; Metallo-supramolecular nanogel ; pH-responsiveness ; Synergistic treatment
• 刊名：Acta Biomaterialia
• 出版年：2015
• 出版时间：1 October 2015
• 年：2015
• 卷：25
• 期：Complete
• 页码：162-171
• 全文大小：2463 K

文摘

Benefited from the high orientation of coordinated interaction, metallo-supramolecular materials have attracted enormous interest in many fields. Herein, a novel metallo-supramolecular nanogel (SNG)-based drug delivery system for synergistic chemo-photodynamic therapy is explored to enhance anticancer efficacy. It is fabricated by the metallo-supramolecular-coordinated interaction between tetraphenylporphyrin zinc (Zn-Por) and histidine. It can respond to tumor acid microenvironment to release the co-delivered anticancer drug and photosensitizer to kill the lesion cells. Zn-Por moieties in SNG keep the photosensitivity in the range of visible wavelength and possess the ability of generating active oxygen species for photodynamic therapy. The drug-loaded SNG provides a di-functional platform for chemotherapy and photodynamic therapy. Compared with the single chemotherapy of free doxorubicine (DOX) or photodynamic therapy of Zn-Por in SNG, DOX-loaded SNG with irradiation shows higher in vitro cytotoxicity and in vivo anticancer therapeutic activity, endowing the SNG with great potential in cancer treatments.

The statement of significance

A combination of multiple non-cross-resistant anticancer agents has been widely applied clinically. Applying multiple drugs with different molecular targets can raise the genetic barriers and delay the cancer adaption process. Multiple drugs targeting different cellular pathways can function synergistically, giving higher therapeutic efficacy and target selectivity. Overall, developing a combination therapeutic approach might even be the key to enhance anticancer efficacy and overcome chemo-resistance. Herein, a novel metallo-supramolecular nanogel (SNG) is fabricated by the metallo-supramolecular-coordinated interaction between tetraphenylporphyrin zinc (Zn-Por) and histidine. The DOX-loaded SNG provides a di-functional platform for chemotherapy and photodynamic therapy because it can respond to tumor acid microenvironment to release the co-delivered anticancer drug and photosensitizer to kill the lesion cells.