In situ cross-linked polysaccharide hydrogel as extracellular matrix mimics for antibiotics delivery

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• 作者：Yu Zhao^a ; Xinge Zhang^a ; ^{zhangxinge@nankai.edu.cn" class="auth_mail} ; Yanan Wang^a ; Zhongming Wu^b ; Jinxia An^a ; Zhentan Lu^a ; Lin Mei^a ; Chaoxing Li^a
• 关键词：Hydrogel ; Polysaccharide ; Antibacterial ; Wound dressing
• 刊名：Carbohydrate Polymers
• 出版年：25 May, 2014
• 年：2014
• 卷：105
• 期：Complete
• 页码：63-69
• 全文大小：2289 K

文摘

Many synthetic hydrogels for drug delivery have been based on polyethylene glycol which is non-natural, non-biodegradable and only terminal-functionalizable. The polysaccharides dextran and chitosan not only are highly hydrophilic, biodegradable and pendant-functionalizable, but also more closely mimic the nature extracellular matrix glycosaminoglycans. Here, a biomimetic hydrogel based on chitosan and dextran was synthesized by the Michael addition reaction. The hydrogels have good swelling and cytocompatibility against NIH3T3. Moreover, vancomycin-loaded hydrogels were formed in situ, and could kill both Gram-positive bacteria and Gram-negative bacteria, indicating that the hydrogel as a wound dressing could provide protection against bacterial infection. Notably, the drug release was controlled via modifying the compositions. Therefore, the biomimetic polysaccharide hydrogels as a promising carrier have potential application for wound healing.