Francisella tularensis intracellular survival: to eat or to die

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• 作者：Monique Barel ; Alain Charbit
• 关键词：Francisella tularensis ; Intracellular parasitism ; Nutritional immunity
• 刊名：Microbes and Infection
• 出版年：December, 2013
• 年：2013
• 卷：15
• 期：14-15
• 页码：989-997
• 全文大小：476 K

文摘

Francisella tularensis is a highly infectious facultative intracellular bacterium causing the zoonotic disease tularemia. Numerous attributes required for F. tularensis intracellular multiplication have been identified recently. However, the mechanisms by which the majority of them interfere with the infected host are still poorly understood. The following review summarizes our current knowledge on the different steps of Francisella intramacrophagic life cycle and expands on the importance of nutrient acquisition.