Calcium and protons affect the interaction of neurotransmitters and anesthetics with anionic lipid membranes
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- 作者：Rosendo Pé ; rez-Isidoro1 ; rosendopi18@gmail.com" class="auth_mail" title="E-mail the corresponding author ; J.C. Ruiz-Suá ; rez ; 1 ; jcrs.mty@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cp ; specific heat capacity at constant pressure ; DPPC ; 1 ; 2-dipalmitoyl-sn-glycero-3-phosphocholine ; DPPA ; 1 ; 2-dipalmitoyl-sn-glycero-3-phosphate (sodium salt) ; DPPG ; 1 ; 2-dihexadecanoyl-sn-glycero-3-phospho-(1&prime ; -rac-glycerol) (sodium salt) ; DMPS ; 1 ; 2-ditetradecanoyl-sn-glycero-3-phospho-l-serine (sodium salt) ; SM ; N-octadecanoyl-d-erythro-sphingosylphosphorylcholine ; ACh ; acetylcholine ; GABA ; γ-aminobutyric acid ; LGlu ; l-glutamic acid ; TC ; tetracaine ; PB ; pentobarbital ; SUV ; sonicated unilam
- 刊名：Biochimica et Biophysica Acta (BBA)-Biomembranes
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：1858
- 期：9
- 页码：2215-2222
- 全文大小：1387 K
文摘
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Charged lipids interact strongly with neurotransmitters (NTs) and anesthetics (ATs).
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Calcium and protons enhance or inhibit the interaction of NTs and ATs with charged lipids.
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ACh is positively charged and the interaction with the phosphatidic acid screened with calcium is repulsive