APOBEC3B-Mediated Cytidine Deamination Is Required for Estrogen Receptor Action in Breast Cancer
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- 作者：Manikandan Periyasamy1 ; Hetal Patel1 ; Chun-Fui Lai1 ; Van T.M. Nguyen1 ; Ekaterina Nevedomskaya2 ; Alison Harrod1 ; Roslin Russell3 ; Judit Remenyi4 ; Anna Maria Ochocka1 ; Ross S. Thomas1 ; Frances Fuller-Pace4 ; Balá ; zs Gy艖rffy5 ; Carlos Caldas3 ; Naveenan Navaratnam6 ; Jason S. Carroll3 ; Wilbert Zwart2 ; R. Charles Coombes1 ; Luca Magnani1 ; Laki Buluwela1 ; Simak Ali1 ; simak.ali@imperial.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：6 October 2015
- 年：2015
- 卷：13
- 期：1
- 页码：108-121
- 全文大小：5006 K
文摘
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APOBEC3B is associated with poor survival in ER+ breast cancer patients
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APOBEC3B controls breast cancer cell growth by promoting ER transcriptional activity
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APOBEC3B can cause C-to-U mutations at ER target genes, to activate DNA repair
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Repair of APOBEC3B-induced lesions allows chromatin remodelling that stimulates gene expression