d="p0150">NIH convened a workshop to address the evidence base for nutritional interventions in primary mitochondrial disease (PMD).
dd><dt class="label">•dt><dd>d="p0155">Dietary supplements are commonly used as management modalities for PMD despite limited evidence of safety and efficacy.
dd><dt class="label">•dt><dd>d="p0160">PMD are rare, clinically, phenotypically, and genetically heterogeneous, a challenge to conducting clinical trials.
dd><dt class="label">•dt><dd>d="p0165">Resources to support clinical trials include patient registries and biorepositories, and common data elements.
dd><dt class="label">•dt><dd>d="p0170">Future research is needed to define the diseases; identify biomarkers, outcome measures, and endpoints.
dd>dl>