International values of corneal elevation in normal subjects by rotating Scheimpflug camera

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• 作者：Matthew T. Feng MD ; Michael W. Belin MD  ; ;   ; ^{mwbelin@aol.com} ; Renato Ambró ; sio Jr. MD ; PhD ; Satinder P.S. Grewal MD ; Wang Yan MD ; PhD ; Mohamed Shafik Shaheen MD ; PhD ; Charlotte A. Jordon BOptom ; Charles McGhee MD ; PhD ; Naoyuki Maeda MD ; Tobias H. Neuhann MD ; H. Burkhard Dick MD ; PhD ; Andreas Steinmueller MSc[Author vitae]
• 刊名：Journal of Cataract and Refractive Surgery
• 出版年：2011
• 出版时间：October 2011
• 年：2011
• 卷：37
• 期：10
• 页码：1817-1821
• 全文大小：275 K

文摘

Purpose

To examine whether clinically significant differences exist in corneal elevation data from a sampling of countries worldwide.

Setting

International multicenter.

Design

Evaluation of diagnostic test or technology.

Methods

One randomly selected eye of normal adults from 8 countries spanning 6 continents was examined using the Pentacam Eye Scanner. Anterior and posterior elevations were measured at the apex and thinnest point. Differences between countries were assessed by Kruskal-Wallis. Normative thresholds were defined according to the Tukey method.

Results

The study examined 1 eye of 555 patients. Median elevations were similar across countries. Upper limits of normal for collective international data were 3.5 ¦Ìm, 6.0 ¦Ìm, 7.5 ¦Ìm, and 13.5?¦Ìm at the anterior apex, anterior thinnest point, posterior apex, and posterior thinnest point, respectively. These and country-specific thresholds were similar to normal values from previous data; however, country-specific thresholds flagged additional eyes in China, Egypt, and India. Those thresholds were 4.5 ¦Ìm at the anterior thinnest point (China and Egypt), 7.4 ¦Ìm at the posterior apex (India), and 11.0 ¦Ìm and 12.0 ¦Ìm at the posterior thinnest point (China and Egypt, respectively).

Conclusions

In general, international variations were clinically insignificant; thus, current screening guidelines maintained their applicability. Notable exceptions were China, Egypt, and India, where country-specific thresholds may better reflect the test populations and minimize potential false negative results from screening.

Financial Disclosure

No author has a financial or proprietary interest in any material or method mentioned. Additional disclosures are found in the footnotes.