Effect of 1,25-dihydroxyvitamin D3 on the Wnt pathway in non-malignant colonic cells
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- 作者：Charlotte Grö ; schela ; Abhishek Aggarwala ; Samawansha Tennakoona ; Julia Hö ; bausa ; Maximilian Prinz-Wohlgenannta ; Brigitte Marianb ; Petra Heffeterb ; c ; Walter Bergerb ; c ; Enikő Ká ; llaya ; enikoe.kallay@meduniwien.ac.at" class="auth_mail" title="E-mail the corresponding author
- 关键词：CRC ; colorectal cancer ; APC ; adenomatous polyposis coli ; 1 ; 25-D3 ; 1 ; 25-dihydroxyvitamin D3 ; CYP24A1 ; 1 ; 25-D3 24-hydroxylase ; 25(OH)2D3 ; 25-dihydroxyvitamin D3 ; TCF ; T-cell factor ; FAP ; familial adenomatous polyposis ; LGR5 ; leucine-rich G-protein coupled receptor 5 ; VDR ; vitamin D receptor
- 刊名：Journal of Steroid Biochemistry and Molecular Biology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：155
- 期：part_PB
- 页码：224-230
- 全文大小：1392 K
文摘
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1,25-D3 increases differentiation in the adenoma cell line LT97.
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1,25-D3 inhibits Wnt target gene expression.
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Vitamin D regulates the Wnt pathway in the healthy mouse colon.